What’s All the Fuss About Organoids? | Tempo Bioscience

In the modern fast-paced worlds of research and medicine, disease models that take us closer to the real-life situation are highly desirable. While we can’t discredit the power of in vitro cell culture methods to provide important clues about biological processes, mechanisms of disease, and response to drugs, the availability of life-like tissue systems such as organoids provides obvious opportunities to study these aspects of human biology in a much more realistic manner. Image Credit: Yale Rosen (
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A two-pronged approach to reduce heart failure in childhood cancer survivors

Anthracyclines such as doxorubicin, daunomycin and darubicin belong to a class of chemotherapeutic drugs that is widely used to treat paediatric cancers. Advances in chemotherapy, other treatment strategies and supportive care have led to significant improvements in paediatric cancer outcomes, with current five-year survival rates exceeding 80%. Improved survival rates mean that there are now more than 400,000 long-term childhood cancer survivors in the U.S, and this number is steadily growing.
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Cutting-edge epigenetics research reveals new genes linked to metabolic syndrome in humans

In multicellular organisms e.g., humans, other animals, and plants, almost every cell contains identical genetic information. However, not all cell types behave in the same way. For example, white blood cells are distinct from bone cells in appearance and function. Chromatin is a dense complex found in the nucleus of the cell that contains the majority of our DNA, along with RNA and associated proteins. It plays a critical role in establishing and maintaining these intracellular differences (or
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Can Genetics Explain Schizophrenia? | Tempo Bioscience

In one of our recent posts, we addressed the types of genetic variability that exist in humans and why a greater understanding of these is critical in diagnostics, for predicting our response to new drugs, and in the development of personalized treatments. Here, we will look at how genetic variability can serve as a tool to expand our understanding of disease susceptibility and mechanisms, using schizophrenia as a case study. Image Credit: Mark Turnauckas
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The Many Faces of Phagocytes | Tempo Bioscience

Most of us were introduced to phagocytosis as a cellular event where dead host cells, microbial cells or their components, or other foreign bodies are engulfed and often destroyed by specialized cells known as phagocytes. During my undergraduate studies, phagocytosis was a small topic within immunology and macrophages were the crème de la crème of phagocytes, patrolling the body’s tissues for foreign invaders, much like security guards patrolling their territories.
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Uncovering new strategies to reduce TB susceptibility in HIV-infected individuals

Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis, is a serious cause of disease and mortality worldwide, especially in developing countries. Co-infection with the human immunodeficiency virus (HIV) aggravates this situation, and puts intense pressure on national healthcare services in sub-Saharan Africa, where up to 80% of TB patients are HIV-infected, and where TB is now the leading cause of death in HIV-infected individuals.
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A multistressor world: marine climate change and its effects on ocean life

Coastal marine ecosystems represent the most diverse and productive parts of the world’s oceans, providing a range of crucial ecosystem services such as food, protection, and recreation to humankind. Unfortunately, coastal ecosystems are threatened due to marine climate change, marked by three related and concomitant oceanic changes: warming, acidification (increased carbon dioxide levels), and declining oxygen levels.
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