Karen O'Hanlon Cohrt

Research Features

Unravelling the signalling cues controlling vertebrate reproductive behaviour

How do vertebrate brains integrate information from external social cues and internal physiological states to produce appropriate behaviours? This is one of the big questions that Dr Karen Maruska and her research team at Louisiana State University (LSU) are striving to answer. Dr Maruska leads a research group that uses fish models to investigate how animals process and translate multisensory social cues into context-specific behaviours for reproduction and survival.
Tempo Bioscience

Alzheimer’s Disease – Hypotheses Old and New – Part Two | Tempo Bioscience

Cover Photo credit: affen ajlfe ( In our last post, we walked through some of the canonical hypotheses surrounding Alzheimer’s Disease (AD), but what about all the other hypotheses that are knocking around? Since AD’s discovery over a century ago countless ideas have emerged, yet the exact cause of this disease remains the holy grail for many neuroscientists. In this post, we will try to spice things up a little by taking a look at one of the less popular AD hypotheses!
Research Features

Reprogramming the immune system for personalised immunotherapy against cancer

For decades, researchers have strived to understand how the immune system recognises and fights cancer, ultimately aiming to exploit and augment these processes to create more effective cancer therapies. Dr Richard Koya, Associate Professor of Oncology, Associate Director of the Center for Immunotherapy, and Director of the Vector Development & Production Facility at Roswell Park Cancer Institute is a prominent researcher in this area. He leads an international team of researchers in developing cutting edge technologies to use patients’ own immune systems to target and kill cancer cells.
Research Features

A shining light in the fight against childhood leukaemia?

Dr C. James Lim, PhD, is an Associate Professor at the Department of Pediatrics, University of British Columbia, as well as Investigator at the Michael Cuccione Childhood Cancer Research Program at British Columbia Children’s Hospital, Vancouver, Canada. His research group aims to unravel the mechanisms underlying acquired resistance to chemotherapy in childhood malignancies, with the goal of identifying new treatment strategies to improve the odds for children fighting this disease.
Tempo Bioscience

Alzheimer’s Disease – Hypotheses Old and New – Part One | Tempo Bioscience

Cover Photo credit: The Alzheimer’s story began when the German physician Dr. Aloysius Alzheimer reported distinctive plaques and neurofibrillary tangles in the brains of deceased individuals in a series of case study reports, published in the early 1900’s. Alzheimer originally coined these features as presenile dementia, and the disease was later renamed by his supervisor, the German psychiatrist, Emil Kraepelin.
Bitesize Bio

Alphabet Soup for Bacteria: Components for Growth

In its simplest form, a bacterial growth medium is designed to support the growth of bacteria. Depending on which bacteria you want to culture, you may have a range of different media to choose from, each containing a rather unique blend of sometimes surprising (and odd!) components! In this article, I will take you through the ABCs of bacterial soup and give you an overview about many of the funky things you may encounter as you strive to feed your bacteria and keep them happy! This article wi
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Top Ten websites to help you with your PCR experiments

Whether you are embarking on a PhD in molecular biology, trying to amplify a new gene, analyzing gene expression by qPCR, or trying to solve a PCR problem, you will probably resort to a Google search at some point or another. How do you sort out the > 20 million hits you get when you Google ‘PCR’? This list of the Top 10 PCR websites contains those used by myself and colleagues and should be a good go-to for any of the following PCR issues: Primer3 is a very simple yet efficient online interfa
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Polymerase chain reaction-enzyme-linked immunosorbent assay (PCR-ELISA)

As researchers, we are constantly on the lookout for new and improved ways to analyze, detect and quantify our favorite protein or gene. Luckily, we don’t always need to reinvent the wheel! PCR-ELISA is a good example of where two commonly used techniques have been merged together to create a very powerful analytical tool. As the name suggests, PCR-ELISA combines an immunological method (ELISA) to detect and quantify specific PCR products directly after immobilization of DNA on a microtiter pla
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