
The Challenges In Small Molecule Drug Development – Part 3 of our Drug Discoveries Series: To Zs and Z’ | Tempo Bioscience
Drug targets may be identified in a number of ways, for example, through studying disease pathophysiology to find disease-relevant pathways, or using genome and transcriptome analysis to identify proteins that are differentially expressed and/or aberrantly translated during disease. The early stages of any drug discovery effort must include extensive target validation, ideally through a broad combination of in vitro and in vivo (animal models), cellular and ‘omics’ approaches.